منابع مشابه
Toxicity of 5-fluorouracil.
Fluorouracil (5-FU) is a relatively unique drug in oncology because administration in different doses and schedules results in dramatically different patterns of qualitative toxicity. In the 41 years 5-FU has been available to the clinical oncologist, a wide variety of doses and schedules of this agent have been used. Infusional schedules are associated with less myelosuppression but may have m...
متن کاملDihydropyrimidinase deficiency and severe 5-fluorouracil toxicity.
Dihydropyrimidinase (DHP) is the second enzyme in the catabolism of 5-fluorouracil (5FU), and it has been suggested that patients with a deficiency of this enzyme are at risk from developing severe 5FU-associated toxicity. In this study, we demonstrated for the first time that in one patient the severe toxicity, after a treatment with 5FU, was attributable to a partial deficiency of DHP. Analys...
متن کاملA case of 5-fluorouracil induced encephalopathy.
Patients with reduced dihydropyrimidine dehydrogenase (DPD) activity are at risk for experiencing serious adverse effects following 5-fluorouracil (5-FU) based chemotherapy. Neurotoxicity is considered an extremely rare side effect of 5-FU. We report here on an unusual case of 5-FU induced encephalopathy. A 38-year-old woman with advanced gastric carcinoma was treated with adjuvant chemotherapy...
متن کاملInvolvement of target gene polymorphisms in 5-Fluorouracil toxicity: a case report.
Personalized medicine is becoming an important tool in oncology, both in preventing disease and in optimizing the treatment of existing cancers. Here we describe the cases of 2 patients with relevant systemic toxicity following 5-fluorouracil (5-FU) therapy and we study the more frequent polymorphisms in the target genes, in particular: (1) the variability in the number of 28-base repetitions p...
متن کاملCASE REPORT 5-Fluorouracil/irinotecan induced lethal toxicity as a result of a combined pharmacogenetic syndrome: report of a case
Combination cancer chemotherapy induced toxicity can be associated with combined pharmacogenetic syndromes. Dihydropyrimidine dehydrogenase (DPD) is the principal enzyme involved in the catabolic detoxification of 5fluorouracil (5FU). A heterozygous G . A transition at the 59 splicing donor consensus sequence in intron 14 leading to exon 14 skipping (IVS14+1 G . A, DPYD*2A) with partial loss of...
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ژورنال
عنوان ژورنال: Journal of Biological Research - Bollettino della Società Italiana di Biologia Sperimentale
سال: 2011
ISSN: 1826-8838
DOI: 10.4081/jbr.2011.4648